Publications

Peer Reviewed Publication List

1.      Sadhu N, Dalan R, Jain PR, Lee CJM, et al.  Metabolome-wide association of carotid intima media thickness identifies FDX1 as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.  medRxiv. 2024.05.14.24307316; doi: https://doi.org/10.1101/2024.05.14.24307316

2.      Peng K-W, Klotz A, Guven A, Kapadnis U, Ravipaty S et al.  Identification and validation of N-acetylputrescine in combination with non-canonical clinical features as a Parkinson’s disease biomarker panel.  Sci. Rep.  2024. 14, 10036. https://doi.org/10.1038/s41598-024-60872-3

3.      Lao DY, Mina TM, Sadhu N, Wong KE, Jain PR et al.  Metabolic variation reflects dietary intake in a multi-ethnic Asian population. medRxiv 2023.12.04.23299350.  doi: https://doi.org/10.1101/2023.12.04.23299350

4.      Beaudoin JJ, Clemens L, Miedel MT, Gough A et al. The combination of a human biomimetic liver microphysiology system with BIOLOGXsym, a quantitative systems toxicology (QST) modeling platform of macromolecules, provides mechanistic understanding of Tocilizumab- and GGF2-induced liver injury.  Int. J. Mol. Sci. 2023, 24(11), 9692; https://doi.org/10.3390/ijms24119692

5.      Miller GM, Ellis JA, Sarangarajan R, Parikh A, Rodrigues LO et al. Hypothesis-agnostic network-based analysis of real-world data suggests ondansetron is associated with lower COVID-19 any cause mortality.  Drugs - Real World Outcomes 2022. 9, 359–375 https://doi.org/10.1007/s40801-022-00303-9

6.      Searfoss R, Shah P, Ofori-Mensa K, Bussberg V et al. Impact of hemolysis on multi-OMIC pancreatic biomarker discovery to derisk biomarker development in precision medicine studies.  Sci Rep  2022 Jan 24;12(1):1186.  doi: https://doi.org/10.1038/s41598-022-05152-8

7.      Li S, Sarangarajan R, Jun T, Kao Y-H, Wang Z, Schadt E, Kiebish MA, Granger E, Narain NR, Chen R, Schadt EE, Li L. Continued in-hospital use of ARB, not ACE-I was associated with significant improvement in mortality and outcomes in African American COVID-19 positive population. J Clin. Invest.  2021  131(19):e151418. https://doi.org/10.1172/JCI151418

8.      Dadali T, Diers AR, Kazerounian S, Muthuswamy SK, Awate P, Ng R, Mogre S, Spencer C, Krumova K, Rockwell HE, McDaniel J, Chen EY, Gao F, Diedrich KT, Vemulapalli V, Rodrigues LO, Akmaev VR, Thapa K, Hidalgo M, Bose A, Vishnudas VK, Moser AJ, Granger E, Kiebish MA, Gesta S, Narain NR, Sarangarajan R. Elevated levels of mitochondrial CoQ10 induce ROS-mediated apoptosis in pancreatic cancer. Sci Rep. 2021 Mar 11;11(1):5749. doi: https://doi.org/10.1038/s41598-021-84852-z

9.      Kiebish MA, Tekumalla P, Ravipaty S, Dobi A, Srivastava S et al. Clinical utility of a serum biomarker panel in distinguishing prostate cancer from benign prostate hyperplasia.  Sci Rep 2021.  11, 15052. https://doi.org/10.1038/s41598-021-94438-4

10.  Lacouture ME, Dion H, Ravipaty S, Jimenez JJ, Thapa K, Grund EM, Benaim E, Tanna N, Luan S, DiTommaso N, Narain NR, Sarangarajan R, Granger E, Berman B, Goldfarb SB. A phase I safety study of topical calcitriol (BPM31543) for the prevention of chemotherapy-induced alopecia. Breast Cancer Res Treat. 2021 Feb;186(1):107-114. doi: https://doi.org/10.1007/s10549-020-06005-6. Epub 2020 Nov 18. PMID:33206291.

11.  Sturtz LA, Wang G, Shah P, Searfoss R, Raj-Kumar PK, Hooke JA, Fantacone- Campbell JL, Deyarmin B, Cutler ML, Sarangarajan R, Narain NR, Hu H, Kiebish MA, Kovatich AJ, Shriver CD. Comparative analysis of differentially abundant proteins quantified by LC-MS/MS between flash frozen and laser microdissected OCT-embedded breast tumor samples. Clin Proteomics. 2020 Nov 7;17(1):40. doi: https://doi.org/10.1186/s12014-020-09300-y. PMID: 33292179; PMCID: PMC7648272.

12.  Hamilton PJ, Chen EY, Tolstikov V, Peña CJ, Picone JA, Shah P, Panagopoulos K, Strat AN, Walker DM, Lorsch ZS, Robinson HL, Mervosh NL, Kiraly DD, Sarangarajan R, Narain NR, Kiebish MA, Nestler EJ. Chronic stress and antidepressant treatment alter purine metabolism and beta oxidation within mouse brain and serum. Sci Rep. 2020 Oct 22;10(1):18134. doi: https://doi.org/10.1038/s41598-020-75114-5. PMID: 33093530; PMCID: PMC7582177.

13.  Sarangarajan R, Winn R, Kiebish MA, Bountra C, Granger E, Narain NR. Ethnic Prevalence of Angiotensin-Converting Enzyme Deletion (D) Polymorphism and COVID-19 Risk: Rationale for Use of Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers. J Racial Ethn Health Disparities. 2020 Sep 8:1–8. doi: https://doi.org/10.1007/s40615-020-00853-0. PMID: 32901433; PMCID: PMC7478439.

14.  Sun J, Patel CB, Jang T, Merchant M, Chen C, Kazerounian S, Diers AR, Kiebish MA, Vishnudas VK, Gesta S, Sarangarajan R, Narain NR, Nagpal S, Recht L. High levels of ubidecarenone (oxidized CoQ10 delivered using a drug-lipid conjugate nanodispersion (BPM31510) differentially affect redox status and growth in malignant glioma versus non-tumor cells. Sci Rep. 2020 Aug 17;10(1):13899. doi: https://doi.org/10.1038/s41598-020-70969-0. PMID: 32807842; PMCID:PMC7431533.

15.  Tolstikov V, Moser AJ, Sarangarajan R, Narain NR, Kiebish MA. Current Status of Metabolomic Biomarker Discovery: Impact of Study Design and Demographic Characteristics. Metabolites. 2020 May 29;10(6):224. doi: 10.3390/metabo10060224. PMID: 32485899; PMCID: PMC734511.

16.  Chi JT, Lin PH, Tolstikov V, Oyekunle T, Chen EY, Bussberg V, Greenwood B, Sarangarajan R, Narain NR, Kiebish MA, Freedland SJ. Metabolomic effects of androgen deprivation therapy treatment for prostate cancer. Cancer Med. 2020 Jun;9(11):3691-3702. doi: 10.1002/cam4.3016. Epub 2020 Mar 31. PMID: 32232974; PMCID: PMC7286468.

17.  Kiebish MA, Cullen J, Mishra P, Ali A, Milliman E, Rodrigues LO, Chen EY, Tolstikov V, Zhang L, Panagopoulos K, Shah P, Chen Y, Petrovics G, Rosner IL, Sesterhenn IA, McLeod DG, Granger E, Sarangarajan R, Akmaev V, Srinivasan A, Srivastava S, Narain NR, Dobi A. Multi-omic serum biomarkers for prognosis of disease progression in prostate cancer. J Transl Med. 2020 Jan 7;18(1):10. doi: 10.1186/s12967-019-02185-y. PMID: 31910880; PMCID: PMC6945688.

18.  Mishra P, Kiebish MA, Cullen J, Srinivasan A, Patterson A, Sarangarajan R, Narain NR, Dobi A. Genomic alterations of Tenascin C in highly aggressive prostate cancer: a meta-analysis. Genes Cancer. 2019;10(5-6):150-159. doi: 10.18632/genesandcancer.196. PMID: 31798767; PMCID: PMC6872669.

19.  Wu WS, Patil S, Gokul K, Tekumalla P, Sharma S, Diers A, Gesta S, Vishnudas V, Sarangarajan R, Kellogg MD, Narain NR, Kiebish MA. Diablo ubiquitination analysis by sandwich immunoassay. J Pharm Biomed Anal. 2019 Sep 5;173:40-46. doi: 10.1016/j.jpba.2019.05.005. Epub 2019 May 3. PMID: 31108422.

20.  Thapa K, Wu KC, Sarma A, Grund EM, Szeto A, Mendez AJ, Gesta S, Vishnudas VK, Narain NR, Sarangarajan R. Dysregulation of the calcium handling protein, CCDC47, is associated with diabetic cardiomyopathy. Cell Biosci. 2018 Aug 17;8:45. doi: 10.1186/s13578-018-0244-0. PMID: 30140426; PMCID: PMC6098598.

21.  Chen E, Kiebish MA, McDaniel J, Niedzwiecka K, Kucharczyk R, Ravasz D, Gao F, Narain NR, Sarangarajan R, Seyfried TN, Adam-Vizi V, Chinopoulos C. Perturbation of the yeast mitochondrial lipidome and associated membrane proteins following heterologous expression of Artemia-ANT. Sci Rep. 2018 Apr 12;8(1):5915. doi: 10.1038/s41598-018-24305-2. PMID: 29651047; PMCID: PMC5897331.

22.  Flores RE, Brown AK, Taus L, Khoury J, Glover F, Kami K, Sarangarajan R, Walshe TE, Narain NR, Kiebish MA, Shelton LM, Chinopoulos C, Seyfried TN. Mycoplasma infection and hypoxia initiate succinate accumulation and release in the VM-M3 cancer cells. Biochim Biophys Acta Bioenerg. 2018 Sep;1859(9):975-983. doi: 10.1016/j.bbabio.2018.03.012. Epub 2018 Mar 23. PMID: 29580805.

23.  Gao F, McDaniel J, Chen EY, Rockwell HE, Nguyen C, Lynes MD, Tseng YH, Sarangarajan R, Narain NR, Kiebish MA. Adapted MS/MS^ALL Shotgun Lipidomics Approach for Analysis of Cardiolipin Molecular Species. Lipids. 2018 Jan;53(1):133-142. doi: 10.1002/lipd.12004. PMID: 29488636; PMCID: PMC6369710.

24.  Jing E, Sundararajan P, Majumdar ID, Hazarika S, Fowler S, Szeto A, Gesta S, Mendez AJ, Vishnudas VK, Sarangarajan R, Narain NR. Hsp90β knockdown in DIO mice reverses insulin resistance and improves glucose tolerance. Nutr Metab (Lond). 2018 Feb 2;15:11. doi: 10.1186/s12986-018-0242-6. PMID: 29434648; PMCID: PMC5796506.

25.  Yang J, Hagen J, Guntur KV, Allette K, Schuyler S, Ranjan J, Petralia F, Gesta S, Sebra R, Mahajan M, Zhang B, Zhu J, Houten S, Kasarskis A, Vishnudas VK, Akmaev VR, Sarangarajan R, Narain NR, Schadt EE, Argmann CA, Tu Z. A next generation sequencing based approach to identify extracellular vesicle mediated mRNA transfers between cells. BMC Genomics. 2017 Dec 22;18(1):987. doi:10.1186/s12864-017-4359-1. PMID: 29273013; PMCID: PMC5741891.

26.  Wu WS, Zhu L, Patil S, Gokul K, Reilly S, Chan J, Tekumalla P, Vishnudas V, Kiebish MA, Sarangarajan R, Akmaev VR, Kellogg MD, Narain NR. Human CCDC47 sandwich immunoassay development with electrochemiluminescence technology. J Immunol Methods. 2018 Jan;452:12-19. doi: 10.1016/j.jim.2017.09.011. Epub 2017 Sep 30. PMID: 28974366.

27.  Drolet J, Tolstikov V, Williams BA, Greenwood BP, Hill C, Vishnudas VK, Sarangarajan R, Narain NR, Kiebish MA. Integrated Metabolomics Assessment of Human Dried Blood Spots and Urine Strips. Metabolites. 2017 Jul 15;7(3):35. doi:10.3390/metabo7030035. PMID: 28714878; PMCID: PMC5618320.

28.  Dowal L, Parameswaran P, Phat S, Akella S, Majumdar ID, Ranjan J, Shah C, Mogre S, Guntur K, Thapa K, Gesta S, Vishnudas VK, Narain NR, Sarangarajan R. Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory Responses. Mediators Inflamm. 2017; 2017:9067049. doi:10.1155/2017/9067049. Epub 2017 Mar 26. PMID: 28458470; PMCID: PMC5385256.

29.  Garg S, Swaminathan V, Dhavala S, Kiebish MA, Sarangarajan R, Narain NR. CoQ10 selective miscibility and penetration into lipid monolayers with lower lateral packing density. Biochim Biophys Acta Biomembr. 2017 Jul;1859(7):1173-1179. doi: 10.1016/j.bbamem.2017.03.021. Epub 2017 Mar 30.PMID: 28366515.

30.  Narain NR, Diers AR, Lee A, Lao S, Chan JY, Schofield S, Andreazi J, Ouro-Djobo R, Jimenez JJ, Friss T, Tanna N, Dalvi A, Wang S, Bunch D, Sun Y, Wu W,Thapa K, Gesta S, Rodrigues LO, Akmaev VR, Vishnudas VK, Sarangarajan R. Identification of Filamin-A and -B as potential biomarkers for prostate cancer. Future Sci OA. 2016 Dec 22;3(1):FSO161. doi: 10.4155/fsoa-2016-0065. PMID:28344825; PMCID: PMC5351499.

31.  Gao F, McDaniel J, Chen EY, Rockwell HE, Drolet J, Vishnudas VK, Tolstikov V, Sarangarajan R, Narain NR, Kiebish MA. Dynamic and temporal assessment of human dried blood spot MS/MS shotgun lipidomics analysis. Nutr Metab (Lond). 2017 Mar 20;14:28. doi: 10.1186/s12986-017-0182-6. PMID: 28344632; PMCID: PMC5360027.

32.  Tolstikov V, Akmaev VR, Sarangarajan R, Narain NR, Kiebish MA. Clinical metabolomics: a pivotal tool for companion diagnostic development and precision medicine. Expert Rev Mol Diagn. 2017 May;17(5):411-413. doi:10.1080/14737159.2017.1308827. Epub 2017 Mar 29. PMID: 28317395.

33.  Ravipaty S, Wu W, Dalvi A, Tanna N, Andreazi J, Friss T, Klotz A, Liao C, Garren J, Schofield S, Diamandis EP, Klein EA, Dobi A, Srivastava S, Tekumalla P, Kiebish MA, Vishnudas V, Sarangarajan R, Narain NR, Akmaev VR. Clinical Validation of a Serum Protein Panel (FLNA, FLNB and KRT19) for Diagnosis of Prostate Cancer. J Mol Biomark Diagn. 2017;8(2):323. doi:10.4172/2155-9929.1000323. Epub 2017 Feb 8. PMID: 29682400; PMCID: PMC5909981.

34.  Vemulapalli V, Qu J, Garren JM, Rodrigues LO, Kiebish MA, Sarangarajan R, Narain NR, Akmaev VR. Non-obvious correlations to disease management unraveled by Bayesian artificial intelligence analyses of CMS data. Artif Intell Med. 2016 Nov;74:1-8. doi: 10.1016/j.artmed.2016.11.001. Epub 2016 Nov 17. PMID: 27964799.

35.  Gao F, McDaniel J, Chen EY, Rockwell H, Lynes MD, Tseng YH, Sarangarajan R, Narain NR, Kiebish MA. Monoacylglycerol Analysis Using MS/MS(ALL) Quadruple Time of Flight Mass Spectrometry. Metabolites. 2016 Aug 17;6(3):25. doi:10.3390/metabo6030025. PMID: 27548241; PMCID: PMC5041124.

36.  Chen E, Kiebish MA, McDaniel J, Gao F, Narain NR, Sarangarajan R, Kacso G, Ravasz D, Seyfried TN, Adam-Vizi V, Chinopoulos C. The total and mitochondrial lipidome of Artemia franciscana encysted embryos. Biochim Biophys Acta. 2016 Nov;1861(11):1727-1735. doi: 10.1016/j.bbalip.2016.08.007. Epub 2016 Aug 16. PMID: 27542539.

37.  Gesta S, Guntur K, Majumdar ID, Akella S, Vishnudas VK, Sarangarajan R, Narain NR. Reduced expression of collagen VI alpha 3 (COL6A3) confers resistance to inflammation-induced MCP1 expression in adipocytes. Obesity (Silver Spring). 2016 Aug;24(8):1695-703. doi: 10.1002/oby.21565. Epub 2016 Jun 17. PMID: 27312141.

38.  Rockwell HE, Gao F, Chen EY, McDaniel J, Sarangarajan R, Narain NR, Kiebish MA. Dynamic Assessment of Functional Lipidomic Analysis in Human Urine. Lipids. 2016 Jul;51(7):875-86. doi: 10.1007/s11745-016-4142-0. Epub 2016 Apr 1. PMID:27038173.

39.  Manga P, Sheyn D, Yang F, Sarangarajan R, Boissy RE. A role for tyrosinase-related protein 1 in 4-tert-butylphenol-induced toxicity in melanocytes: Implications for vitiligo. Am J Pathol. 2006 Nov;169(5):1652-62. doi:10.2353/ajpath.2006.050769. PMID: 17071589; PMCID: PMC1780195.

40.  Sarangarajan R, Apte SP. The polymerization of melanin: a poorly understood phenomenon with egregious biological implications. Melanoma Res. 2006 Feb;16(1):3-10. doi: 10.1097/01.cmr.0000195699.35143.df. PMID: 16432450.

41.  Sarangarajan R, Apte SP, Ugwu SO. Hypoxia-targeted bioreductive tyrosine kinase inhibitors with glutathione-depleting function. Anticancer Drugs. 2006 Jan;17(1):21-4. doi: 10.1097/01.cad.0000185179.34486.a3. PMID: 16317286.

42.  Sarangarajan R, Apte SP. Melanization and phagocytosis: implications for age related macular degeneration. Mol Vis. 2005 Jul 7;11:482-90. PMID: 16030499.

43.  Sarangarajan R, Apte SP. Melanin aggregation and polymerization: possible implications in age-related macular degeneration. Ophthalmic Res. 2005 May- Jun;37(3):136-41. doi: 10.1159/000085533. Epub 2005 May 3. PMID: 15867475.

44.  Sarangarajan R, Apte SP. Ocular melanogenesis: the role of antioxidants. Ophthalmic Res. 2004 Nov-Dec;36(6):303-11. doi: 10.1159/000081632. PMID: 15627830.

45.  Sarangarajan R, Cacini W. Early onset of cisplatin-induced nephrotoxicity in streptozotocin-diabetic rats treated with insulin. Basic Clin Pharmacol Toxicol. 2004 Aug;95(2):66-71. doi: 10.1111/j.1742-7843.2004.950204.x. PMID: 15379782.

46.  Grover B, Auberger C, Sarangarajan R, Cacini W. Functional impairment of renal organic cation transport in experimental diabetes. Pharmacol Toxicol. 2002 Apr;90(4):181-6. doi: 10.1034/j.1600-0773.2002.900402.x. PMID: 12076311.

47.  Le Poole IC, Sarangarajan R, Zhao Y, Stennett LS, Brown TL, Sheth P, Miki T, Boissy RE. 'VIT1', a novel gene associated with vitiligo. Pigment Cell Res. 2001 Dec;14(6):475-84. doi: 10.1034/j.1600-0749.2001.140608.x. PMID: 11775060; PMCID:PMC1747534.

48.  Sarangarajan R, Boissy RE. Tyrp1 and oculocutaneous albinism type 3. Pigment Cell Res. 2001 Dec;14(6):437-44. doi: 10.1034/j.1600-0749.2001.140603.x. PMID: 11775055.

49.  Sarangarajan R, Budev A, Zhao Y, Gahl WA, Boissy RE. Abnormal translocation of tyrosinase and tyrosinase-related protein 1 in cutaneous melanocytes of Hermansky-Pudlak Syndrome and in melanoma cells transfected with anti-sense HPS1 cDNA. J Invest Dermatol. 2001 Sep;117(3):641-6. doi:10.1046/j.0022-202x.2001.01435.x. PMID: 11564171.

50.  Huizing M, Sarangarajan R, Strovel E, Zhao Y, Gahl WA, Boissy RE. AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes. Mol Biol Cell. 2001 Jul;12(7):2075-85. doi: 10.1091/mbc.12.7.2075. PMID: 11452004; PMCID:PMC55657.

51.  Sarangarajan R, Shumaker H, Soleimani M, Le Poole C, Boissy RE. Molecularand functional characterization of sodium--hydrogen exchanger in skin as well as cultured keratinocytes and melanocytes. Biochim Biophys Acta. 2001 Mar 9;1511(1):181-92. doi: 10.1016/s0005-2736(01)00273-5. PMID: 11248216.

52.  Sarangarajan R, Zhao Y, Babcock G, Cornelius J, Lamoreux ML, Boissy RE. Mutant alleles at the brown locus encoding tyrosinase-related protein-1 (TRP-1) affect proliferation of mouse melanocytes in culture. Pigment Cell Res. 2000 Oct;13(5):337-44. doi: 10.1034/j.1600-0749.2000.130506.x. PMID: 11041210.

53.  Le Poole IC, Boissy RE, Sarangarajan R, Chen J, Forristal JJ, Sheth P, Westerhof W, Babcock G, Das PK, Saelinger CB. PIG3V, an immortalized human vitiligo melanocyte cell line, expresses dilated endoplasmic reticulum. In Vitro Cell Dev Biol Anim. 2000 May;36(5):309-19. doi:10.1290/1071-2690(2000)036<0309:PAIHVM>2.0.CO;2. PMID: 10937834.

54.   Yang F, Sarangarajan R, Le Poole IC, Medrano EE, Boissy RE. The cytotoxicity and apoptosis induced by 4-tertiary butylphenol in human melanocytes are independent of tyrosinase activity. J Invest Dermatol. 2000 Jan;114(1):157-64. doi: 10.1046/j.1523-1747.2000.00836.x. PMID: 10620132.

55.  Sarangarajan R, Cacini W. Normalization of hyperglycaemia by oral vanadyl sulfate does not reverse diabetes-induced protection against cisplatin nephrotoxicity in streptozotocin-diabetic rats. Pharmacol Toxicol. 1999 Oct;85(4):169-73. doi: 10.1111/j.1600-0773.1999.tb00087.x. PMID: 10563515.

56.  Sarangarajan R, Dhabia N, Soleimani M, Baird N, Joiner C. NHE-1 is the sodium-hydrogen exchanger isoform present in erythroid cells. Biochim Biophys Acta. 1998 Sep 23;1374(1-2):56-62. doi: 10.1016/s0005-2736(98)00130-8. Erratum in: Biochim Biophys Acta. 2004 Nov 17;1667(1):101. Soliemani, M [corrected to Soleimani, M]. PMID: 9814852.

57.  Sarangarajan R, Cacini W. Diabetes-induced protection from cisplatin nephrotoxicity is associated with impairment of energy-dependent uptake by renal cortex slices. Pharmacol Toxicol. 1997 Oct;81(4):197-8. doi:10.1111/j.1600-0773.1997.tb02068.x. PMID: 9353851.

58.  Sarangarajan R, Cacini W. Effect of route of administration and dose on diabetes-induced protection against cisplatin nephrotoxicity. Proc Soc Exp Biol Med. 1996 Sep;212(4):362-8. doi: 10.3181/00379727-212-44027. PMID: 8751995.

59.  Herzog KM, Deutsch E, Deutsch K, Silberstein EB, Sarangarajan R, Cacini W. Synthesis and renal excretion of technetium-99m-labeled organic cations. J Nucl Med. 1992 Dec;33(12):2190-5. PMID: 1460514.